Mellor Health Solutions Newsletter
December 2020

Intermittent Fasting Schedule Improves Insulin Sensitivity

In relatively healthy men, early time-restricted feeding (eTRF) may improve insulin sensitivity and skeletal muscle glucose uptake, according to results of a new study.

"Altering the temporal distribution of energy intake and introducing periods of intermittent fasting exert important metabolic effects," the researchers wrote. "Restricting [energy intake] to earlier in the day is a novel type of [intermittent fasting]."

To conduct their study, the researchers enrolled 16 healthy men presenting at the University of Nottingham. All participants were aged between 18 and 35 years, had a body mass index between 18 and 27 kg/m2, and had reported moderately active physical activity.

The participants were then assigned to 1 of 2 groups. The eTRF (n = 8) group consumed their daily energy between 8:00 am and 4:00 pm for 2 weeks, and the control/caloric restriction (n = 8) group was a control group that matched the reduction in energy intake and weight loss observed in eTRF. The control intervention was completed after the eTRF intervention.

All participants also consumed a carbohydrate/protein drink before and after the interventions, and their metabolic responses were measured before and 180 minutes after consumption.

The researchers results showed that compared with participants in the control/caloric restriction group, those in the eTRF group experienced improved whole-body insulin sensitivity, skeletal muscle uptake of glucose, and branched-chain amino acids.

In addition, participants in the eTRF group also experienced a reduction in energy intake (about 400 kcal/day−1) and reduction in weight (−1.04 - 0.25 kg; P = .01), which was matched in the participants of the control/caloric restriction group (−1.24 - 0.35 kg; P = .01).

"Under free-living conditions, eTRF improves whole-body insulin sensitivity and increases skeletal muscle glucose and [branched-chain amino acids] uptake," the researchers wrote. "The metabolic benefits of eTRF are independent of its effects on weight loss and represent chronic adaptations rather than the effect of the last bout of overnight fast."


Jones R, Pabla P, Mallinson J, et al. Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men. Am J Clin Nutri. 2020;112(4):1015-1028.

Our newsletter is created as an educational resource that provides patients with education, information and the best choices in natural Health care and Wellness.

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At Mellor Health Solutions our focus is on the Whole Family and their Best Health. We are a successful Health and Wellness Clinic with three decades of experience. We excel at Designed Clinical Nutrition programs for every individual in the Family and every need of the individual. We utilize the "Cellular Healing Diet" from Dr.Pompa, Nutrition Response Testing, Neural Organizational Technique, Meridian BioFeedack analysis , Nutritional supplements, Herbal supplements, and Homeopathy to restore Your Health. We are excited about of our very successful and popular comprehensive Weight loss program that we have combined with Dr.Pompas "Cellular Healing Diet". Our program is available for restoring your lean body mass, youthful looks and optimum Health. Better yet the combination of the two lifestyle changes grant you the ability to maintain not only your natural lean body mass and weight, but true Health as well! And we offer Chiropractic care that helps remove interferences within the body and helps reestablish neurological organization and balance with emphasis on identifying the underlying cause. Please contact us with any questions and for a consultation to see what we can do for you and your Health concerns. We are looking forward to talking with you soon.

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